Protein Details: Amiloride-sensitive sodium channel subunit alpha
Protein ID
ICDB_Pro_1620
Protein Name
Amiloride-sensitive sodium channel subunit alpha
Gene Name
SCNN1A; ENAC
Organism
Cavia porcellus (Guinea pig)
Length
682 amino acids
AlphaFoldDB
AF-Q9R1N2-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney; colon; lung and eccrine sweat glands. Also plays a role in taste perception.
Sequence
MLMRLLPLPSLTDGRPLGCCCTCQGSMKGDELKAQGPLPPQPLQGPLKGDKCEQPGLGPEPTAPQQHTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFGEYFSYPVSLNINLNSDKLVFPAVTVCTLNPYRYKEIKEQLRELDRITQQTLFDLYNYNASSTLLAGARSRRSLADTLPYPLQRIPVQPEPRRARSSDPSSVRDNNPRVDRRDWRVGFQLCNQNKSDCFYQTSSSGVDGVREWYRFHYINILAQVADTSPRWEEETLGNFIFACRFNQAPCTQENYSHFHHPIYGNCYTFNNKNDSSLWMASMPGINNGLSLTLRTEQNDYIPLLSTVTGARVTVHGQDEPAFMDDGGFNLRPGVETSISMRKEALDRLGGSYGDCTQDGSDVPVQNLYPSKYTQQVCIHSCFQENMIKQCGCAYIFYPKPKGVEFCDYTNHSAWGYCYYKLQGAFSSDSLGCFNKCRKPCNVTIYKLSAGYSRWPSAASQDWIFQMLSLQNNYTISNKRNGVAKLNIYFKELNYRTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAEFMFDLLVITLLMLLRRFRSRYWSPGRGARAAREVACTPPPSLPSRFCAHSAFPTLTAPPPAYATLSACPPLQGLAGASSAACAPREP
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1007/s004249900213; 10.1111/j.1469-7793.2000.t01-2-00147.xm